There is no doubt that the pharmaceutical industry is changing rapidly. There has been a major swing in the type of therapeutic agents being developed in this industry- most notably within big pharma. More changes are coming. One well-documented major change is the move away from small molecule development towards large molecules in the industry

The European Biocidal Products Directive (98/8/EC) aims to establish, via a mandatory authorisation scheme, a single market in biocides that provides a high level of protection for man and the environment by ensuring that requirements for authorisation of products are equal across all Member States. An integral part of such controls is the requirement that products will be effective in use.

Lichens growing on rocks determine physico-chemical deterioration processes which can turn into a problem when the colonization occurs on historically or culturally significant stone substrata. Since 1990s, by joining a multidisciplinary approach and technical advances, researchers have developed new protocols in the analysis of lichen-rock interactions, highlighting their complexity and variability depending on species and lithotypes

Multiphase hydrogenation using heterogeneous catalyst was conducted in a glass continuous flow reactor from Corning at the Centre for Process Innovation. The effect of temperature, hydrogen molar ratio, residence time, catalyst content and concentration were studied using noble-metal slurry catalyst.

The acronym REACH triggers negative emotions all around in industry. The aim of this brief essay is to make a resolute call for optimism “for all that”. Everybody in the European chemical and related industries should be aware that endless lamenting is not helping the industrial location Europe, but, on the opposite, ruining it

Based on bibliometric analysis, this paper explores China’s publication activity in chemistry. China develops fast in chemical research and has taken a leading position in publishing journal papers. International collaboration plays a role in the Chinese chemical community, but this role varies among subfields

CPhI 2009 ( Madrid 13th Oct. - 15th Oct.) according to the Show organizers was meant to be characterized by a fall in number of visitors because of tightening budgets for travels in corporate companies in concomitance of other events. Provisional figures from organizers UBM International Media, instead, showed a 5% increase in visitors over the record 2008 events in Frankfurt. Subject to audit, total attendance was over 25,450 - only 300 below last year

We describe the light-directed in situ synthesis of rU-DNA chimeric oligonucleotides on microarrays. An RNase A assay was performed as �proof-of-principle� to demonstrate the value of such microarrays for studying enzyme kinetics and specificity on RNA based libraries

Research peptide market is important but not well characterized. Since there are no stringent regulations and the market is seemingly price driven, it is unclear what other factors the researchers consider when purchasing custom peptides. Our market research study found that quality is the most important factor and the researchers are willing to trade price preference for better quality

While the role of protein dynamics in enzyme catalysis has been widely recognised, evidence is now accumulating against the traditional view that enzymes require well defined folded structures for their enzymatic activity. Enzymatically active protein molecules have been found to populate a number of conformations, ranging from partially structured states with molten globule features to fully unfolded ensembles

The preparation of large amounts of recombinant protein is a major bottleneck for many areas of scientific research, including structural proteomics and therapeutic drug discovery. Recently, the Small Ubiquitin-like Modifier (SUMO)-based fusion tag technology has gained increasing use for the expression of recombinant proteins. In E. coli recombinant proteins expressed as SUMO fusions have demonstrated enhanced stability and solubility, leading to greatly increased yields (5 to 20-fold) over constructs lacking this tag

We describe and review the application of europium (Eu3+) nanoparticle (NP)-based immunoassays (ENIA) for rapid, sensitive, and quantitative detection of pathogens through antibody-antigen recognition. The extremely intense luminescence of the NPs can be directly detected without the need for enzymatic signal amplification or sample preparation. Incorporation of biotinylated anti-streptavidin (SA) and SAcoated Eu3+ molecules or tyramide molecules for signal amplification (TSA) results in enhanced signal intensity, and further improves detection sensitivity of E

A long standing problem of conventional cancer chemotherapy is the lack of tumour specificity. Tumour-targeting drug delivery systems have been explored to overcome this problem. These systems combine a powerful cytotoxic anticancer agent with a tumour-targeting molecule via a suitable linker to form highly efficacious drug-conjugates. These conjugates can deliver potent cytotoxic drugs specifically to tumours and cancer cells with minimal systemic toxicity

This perspective presents an overview of waste-to-energy (WTE) incineration in China, outlining the demand for municipal solid waste (MSW) incineration, the development of WTE, and the control of air pollution from waste incineration; it also gives an outlook on WTE in addressing China’s MSW disposal and supplying clean energy. Incineration is currently the second most important way of MSW management in China

A bibliometric analysis of data from the Scopus database was performed to assess Chemistry publishing activity in Spain. Results show a slight decrease in Chemistry publication output with respect to total output in Spain, similar to that observed in other regions in the world, and a slight increase in the number of citations

The chemical industry is the fourth economic sector in Spain and it accounts for 10 percent of the Spanish GDP. However, the global crisis has hit the chemical industry in Spain more violently than that in the rest of Europe. The chemical firms supplying the buildings and automotive industries have been particularly hit. In order to revert the trend, and recoup competitiveness, it is necessary to strengthen logistic and communications networks, reduce the cost of electricity, temper the European legislative initiatives in the technical, enviromental and industrial safety fields, and give a new impulse to innovation and investment – both public and private – in R&D

The Italian association CDTec (Associazione Italiana Chimica e Tecnologia delle Ciclodestrine) was founded in 2007 with the purpose of spreading up-to-date knowledge on cyclodextrin chemistry and assuming the role of interface between fundamental research and technology. Low cost scientific meetings, a Web platform and an on-line database are an effective tool for the scientific and industrial community