Home Matching the potential of Process Intensification technologies like continuous manufacturing/flow chemistry with the emerging Societal and Business Challenges in Medicines Manufacture and Supply. Part 2 – Technological Solutions
Vol. 40 | Vol. 40(4) - July / August 2022 | FLOW CHEMISTRY

Matching the potential of Process Intensification technologies like continuous manufacturing/flow chemistry with the emerging Societal and Business Challenges in Medicines Manufacture and Supply. Part 2 – Technological Solutions

by cyb2025
A. L. Rutter

ANDREW L. RUTTER
rutterdesign, Saffron Walden, Essex, United Kingdom

ABSTRACT

Flow Chemistry and Continuous Manufacture offer a wider set of chemical transformations for industrial manufacturing processes and in doing so allows intensification and simplification of synthetic routes to complex organic molecules. This technological approach alone does not address the emerging needs for supply of products like medicines; that of a sustainable and resilient supply base that can quickly supply patients. This requires the addition of new approaches to Automation, Digitalisation, Modularity and Modelling to the functionality of Flow Chemistry to achieve a transformation of the design processes and the supply chain for medicine manufacture.

INTRODUCTION
Part 1 of this paper outlined the societal need for change in the way medicines are supplied, namely reliance of supply and speed of supply, the technological solutions need to have these interlinked attributes and are discussed in this paper.

ABOUT THE AUTHOR

Andrew Rutter FREng, is a consultant specialising in Advanced Manufacturing Technologies, and the economics of supply chains. He advises pharmaceutical companies, governments, and equipment suppliers on programmes to adopt technologies like Continuous Manufacture, and Modularisation.

He is a Visiting Professor at Strathclyde University, and is actively researching methodologies for linking Chemistry, Engineering and Supply Chain decisions. Prior to consulting, he spent 20 years leading GSK’s Advanced Manufacturing Programme, and was a member of ICH Q13 Expert Working Group.

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