Sygnature Discovery have had great success using the Asia Flow Chemistry System from Syrris to safely work with two hazardous reagents on a considerable scale.
Syrris, a leading developer of advanced flow chemistry systems, today announced the publication of a customer case study featuring Sygnature Discovery, who have successfully completed synthesis of a nitroarene bearing an acid-sensitive functional group on a decagram scale and the safe reaction of neopentyl iodide with t-butyllithium using Syrris Asia Flow Chemistry System.
Dr. Raminder Mulla, Lead Scientist, at Sygnature Discovery’s Nottingham laboratory, oversaw two workflows focusing on the oxidation of an aniline to a nitrate and the safe reaction of neopentyl iodide with t-butyllithium at scale. Using Asia, Sygnature Discovery were able to scale up the oxidation of an aniline to a nitrate by 83% and safely conduct the reaction of neopentyl iodide with t-butyllithium.
Asia was able to provide an easy-to-use chemistry platform that gave Sygnature Discovery greater control over their process than traditional batch reactors, both reducing the cost and risk associated with these applications.
“We couldn’t run oxidation of an aniline to a nitroarene at the desired scale in batch reactors as oxidant would accumulate and possibly detonate. Asia provided us with an easy-to-use flow chemistry platform in which to perform this scale-up, including a syringe pump capable of working against high back-pressures and modules such as the chip heater that could be adapted to work with third party equipment.”
– Dr. Raminder Mulla, Lead Scientist, Sygnature Discovery
“Scaling up with Asia was a simple process where we ran the system for longer periods to get our desired results. Asia Syringe Pump’s complete infusion of the syringe contents made purging of residual t-BuLi reagent an easy process, allowing for a highly controlled, productive, synthesis.”
– Dr. Raminder Mulla, Lead Scientist, Sygnature Discovery
Syrris is a world leader in flow chemistry, batch chemistry reactor systems, and chemical scale-up solutions. The award-winning Asia Flow Chemistry System is a versatile flow chemistry platform that can support easy scale up of a vast range of chemistry applications. As Sygnature Discovery found, Asia enables more chemistry to be done, allowing the user to mitigate risk through enhanced process control, reducing the need for large volumes of reagents, and enabling sophisticated, rapid optimization of processes that would be challenging in conventional batch reactors.
Sygnature Discovery is a world-leading integrated drug discovery CRO based in the UK and Canada with headquarters in Nottingham, UK. Sygnature Discovery prides itself on offering a unique, high-quality, distinctive, and tailored integrated drug discovery service to their clients. They have a proven track record of solving challenging synthetic chemistry problems in new and creative ways, opening the scope of chemical space available for projects and generating novel intellectual property. The full case study can be read here: https://www.syrris.com/customer-stories/sygnature-discovery/
