Gauthier Croix, Business development, Chemium
Can you explain the unique aspects of Chemium’s continuous flow technology for producing
Can you explain the unique aspects of Chemium’s continuous flow technology for producing
The current discussion surrounding the role of artificial intelligence (AI) in chemistry often centers on the provocative question of whether AI will supplant chemists in the laboratory. Such debates, while stimulating, tend to overshadow a more pressing and realistic consideration. At present, there is little evidence to suggest that AI will replace experimental chemists in research laboratories in the foreseeable future. However, a critical aspect frequently overlooked in these discussions is the competitive advantage that AI confers. Chemists who adeptly integrate AI into their research methodologies are likely to surpass their peers who do not adopt these advanced tools. This shift in research dynamics underscores the importance of embracing AI not as a replacement but as a powerful ally in the evolving landscape of chemical research. This article was written to demystify the capabilities and limitations of AI in modern chemical research, and to provide a balanced perspective on how AI tools can be effectively integrated without wasting the essential human element in scientific discovery.
Adverse event (AE) case intake, in its current form, is one of the most overlooked and broken workflows in biopharma, so it is ripe for disruption by next-generation AI technologies. After several years of bold promises, Generative AI and Large Language Models are now tangibly delivering human-like decision-making, leading to earlier and more accurate conclusions about Safety events, to enable real-time interventions. ArisGlobal’s Emmanuel Belabe assesses how far the technology has come in delivering intelligent, automated case intake; the tangible difference this is already making; and the wider opportunity for reinventing pharma R&D operations.
In the dynamic landscape of pharmaceutical outsourcing, Rick L. Knight, Global Head, Strategic Account Management at Pfizer CentreOne, reveals how biotech and pharma companies are increasingly turning to contract development and manufacturing organizations (CDMOs) for support in overcoming capacity constraints, accessing specialized expertise and accelerating time-to-market. He explores how integrated CDMOs (those embedded within leading pharmaceutical companies) offer distinct advantages, including established supplier relationships, access to cutting-edge facilities and deep regulatory knowledge to help bring therapies to patients sooner.
This article aims to elucidate the dynamics and intricacies of Contract Development and Manufacturing Organizations (CDMOs), mainly for small molecules in the chemical pharmaceutical industry, contrasting them with traditional outsourcing practices. It explores the critical factors for success, including the balance between hard factors (infrastructure, technology) and soft factors (customer orientation, reliability). The piece discusses the historical context, market trends, and future projections, highlighting the competitive landscape and challenges faced by both established and emerging CDMOs. Recent market data and strategic advice for navigating this complex industry are presented.
We are in the middle of a “hype-cycle” (1) regarding artificial intelligence(AI). For better
G. Thomas Caltagirone, Ph.D. President & CEO, APTAGEN Labs, Jacobus How has the
In recent years, fast flow solid-phase peptide synthesis (FF-SPPS) has been embraced by industry as way to quickly synthesise new peptide-based drugs for the discovery space. By applying uniform heating and inhibiting the movement of resin beads, high reaction efficiency is achieved, while also preventing β-sheet structure formation, thereby improving solubility of peptides as they are synthesised.
Using the FF-SPPS approach, protocols have been developed that work for both long peptides and for sequences where the peptides aggregate. These protocols achieve maximum cycle efficiency by flowing reagents in a single pass through the resin.
By way of example the suitability of FF-SPPS is illustrated by the synthesis of a 77-mer α-helical coiled coil peptide, with a synthesis time of under 20 hours and achieving a crude purity of ~62 %.
A further example is discussed for the linear scale up of a GLP-1 analogue where the use of FF-SPPS, results in a 300X scalability factor without further optimisation. The synthesis time for this GLP-1 analogue at 15 mmol scale is 15 hours with and crude purity of ~80 %.
Day 1 – June 25 Lars Holmberg, PeptiSystems AB (Plenary session) Past and future
This news section features recent discoveries (December 2023 – April 2024) for developing, modifying and delivering therapeutic peptides and oligonucleotides and is divided in categories: discovery, development, delivery, RNA.
The selection was made searching on Google and Pubmed, with the following keywords: peptides news, peptides discovery, peptides development, peptides manufacturing, peptides delivery, oligonucleotides therapy, mRNA.